2017/02/24

Missing Heritability is a serious problem for the theory of evolution

Message of the Missing Heritability Problem: Gene sequences don't determine traits

https://en.wikipedia.org/wiki/Missing_heritability_problem

Excerpt: "The "missing heritability" problem can be defined as the fact that single genetic variations cannot account for much of the heritability of diseases, behaviors, and other phenotypes. This is a problem that has significant implications for medicine, since a person's susceptibility to disease may depend more on "the combined effect of all the genes in the background than on the disease genes in the foreground", or the role of genes may have been severely overestimated."

My comment: The Missing Heritability problem is a very inconvenient fact for evolutionists. There are several scientific facts pointing out that genetic variations don't correlate with diseases, behavior or any other heritable traits. For example, at least seven different lactase persistence gene alleles are known. Which one is the correct one?

There are about 200,000 disease-causing genetic mutations known in the human DNA but not a single mutation is reliably associated with certain disease. (http://www.hgmd.cf.ac.uk/ac/index.php)  About 1,000,000 SNPs (Single Nucleotide Polymorphism) in the human genome have been mapped but no one of them is linked to heritable traits. How is the Missing Heritablity problem solved?

Here's a brief summary of discoveries made by modern science that resolves the Missing Heritability problem:

VARIATION:

- Variation of organisms is based on epigenetic control of gene expression.
- The most important factors influencing the epigenome are diet, climate, stress and toxins.
- microRNAs regulate gene expression, siRNAs transmit correct levels of methylation
- Aberrant methylation patterns trigger sequence changes.
- Sequence changes are genetic errors and they burden the genome. That's why they are hided by histone methylation, chromatin remodeling or chromosome loss.

HERITABILITY:

- Embryonic cells undergo almost complete epigenetic reprogramming within vertebrates. Innate immune system is not erased.
- A cell that lacks the epigenetic layers and markers is a stem cell without a task.
- The epigenome is re-established by maternal and paternal miRNAs, piRNAs, siRNAs and other short non coding RNA molecules during embryonic development and pregnancy

CONCLUSION:

- There are no mechanisms for large scale evolution. Loss of biological information is a scientific fact within all types of organisms.
- Rapid rates of variation and genomic degradation point to design and creation.