A Novel Combination of Withaferin A and Sulforaphane have numerous anti-cancer effects

A Novel Combination of Withaferin A and Sulforaphane have numerous anti-cancer effects


Excerpt: "With cancer often classified as a disease that has an important epigenetic component, natural compounds that have the ability to regulate the epigenome become ideal candidates for study. Humans have a complex diet, which illustrates the need to elucidate the mechanisms of interaction between these bioactive compounds in combination. 
The natural compounds withaferin A (WA), from the Indian winter cherry, and sulforaphane (SFN), from cruciferous vegetables, have numerous anti-cancer effects and some report their ability to regulate epigenetic processes. Our study is the first to investigate the combinatorial effects of low physiologically achievable concentrations of WA and SFN on breast cancer cell proliferation, histone deacetylase1 (HDAC1) and DNA methyltransferases (DNMTs). No adverse effects were observed on control cells at optimal concentrations. There was synergistic inhibition of cellular viability in MCF-7 cells and a greater induction of apoptosis with the combinatorial approach than with either compound administered alone in both MDA-MB-231 and MCF-7 cells. HDAC expression was down-regulated at multiple levels. Lastly, we determined the combined effects of these bioactive compounds on the pro-apoptotic BAX and anti-apoptotic BCL-2 and found decreases in BCL-2 and increases in BAX. 

Taken together, our findings demonstrate the ability of low concentrations of combinatorial WA and SFN to promote cancer cell death and regulate key epigenetic modifiers in human breast cancer cells."

My comment: "Serious science makes such discoveries almost daily when focusing on epigenetic regulatory mechanisms." Pseudoscientists claim that cancers are just bad luck. Most cancers are results from aberrant methylation patterns caused by oxidative stress, poor diet, bad life habits or viruses. This often leads to genetic mutations but they are not the actual reason for cancers. You can take care of your epigenome and impact your health, your childrens' health and your grandchildrens' health. Life is not driven by gene sequences, genes are driven by lifestyle. Don't get lost.